Fibrinogen (factor I) originates in the liver and is converted to fibrin during clotting. Because fibrin is necessary for clot formation, fibrinogen deficiency can produce mild-to-severe bleeding disorders.
This test is used to determine the amount of fibrinogen present in a blood sample. Note that fibrinogen deficiency may also be indicated by prolonged activated partial thromboplastin time, prothrombin time, and thrombin time.
Procedure and posttest care
Reference valuesFibrinogen levels normally range from 175 to 350 mg/d1
Depressed fibrinogen levels may indicate congenital afibrinogenemia; hypofibrinogenemia or dysfibrinogenemia; disseminated intravascular coagulation; fibrinolysis; severe hepatic disease; cancer of the prostate, pancreas, or lung; or bone marrow lesions. Obstetric complications or trauma may cause low levels.
Markedly decreased fibrinogen levels impede the accurate interpretation of coagulation tests that have a fibrin clot as an end point.
Elevated levels may indicate cancer of the stomach, breast, or kidney, or inflammatory disorders, such as pneumonia or membranoproliferative glomerulonephritis.
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