Fibrin Split Products
After a fibrin clot forms in response to vascular injury, the clot is eventually degraded by plasmin, a fibrin-dissolving enzyme. The resulting fragments arc known as fibrin split products (FSP), or fibrinogen degradation products. In this test, FSP are detected in the diluted serum that is left in a blood sample after clotting.
Procedure and posttest care
Serum contains less than 10 ug/ml of FSP. A quantitative assay shows levels of less than 3 ug/ml.
FSP levels increase in primary fibrinolytic states, due to increased levels of circulating profibrinolysin; in secondary states, due to DIC and subsequent fibrinolysis; and in alcoholic cirrhosis, preeclampsia, abruptio placentae, congenital heart disease, sunstroke, bums, intrauterine death, pulmonary embolus, deep-vein thrombosis (transient increase), and myocardial infarction (after 1 or 2 days). FSP levels usually exceed 100ug/ml in active renal disease or renal transplant rejection.
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