A D-dimer is an asymmetrical carbon compound fragment formed after thrombin converts fibrinogen to fibrin, factor XIIIa stabilizes it into a clot, and plasma acts on the cross-linked, or clotted, fibrin. The test is specific for fibrinolysis because it confirms the presence of fibrin split products.
Procedure and posttest care
Normal D-dimer test results are negative or < 250 ug/ml).
Increased D-dimer values may indicate DIC, pulmonary embolism, arterial or venous thrombosis, neoplastic disease, pregnancy (late and postpartum), surgery occurring up to 2 days before testing, subarachnoid hemorrhage (spinal fluid only), or secondary fibrinolysis.
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