Heinz Bodies Test
Heinz bodies are particles of decomposed hemoglobin that precipitate from the cytoplasm of red blood cells (RBCs) and accumulate on RBC membranes. Although Heinz bodies are removed from RBCs by the spleen, they're a major cause of hemolytic anemias.
Heinz bodies can be detected in a whole blood sample using phase microscopy or supravital stains; when they don't form spontaneously, various oxidant drugs may be added to the sample to induce their formation.
Procedure and posttest care
A negative test result indicates an absence of Heinz bodies
The presence of Heinz bodies - a positive test result - may indicate an inherited RBC enzyme deficiency, the presence of unstable hemoglobin, thalassemia, or drug-induced RBC injury. Heinz bodies may also be present after splenectomy
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